Clinical Research in Oral Health

"This book should be bought by anyone having more than just an interest in research and who is involved in commissioning, funding, planning, undertaking or evaluating research. For everyone else, starting off with more generalised texts and using this book for information on specific subject areas would be more appropriate." (Primary Dental Care and Team in Practice, 1 April 2011)

William V. Giannobile is a William K. & Mary Anne Najjar Endowed Professor of Dentistry and Biomedical Engineering at the University of Michigan. He is also the Director of the Michigan Center for Oral Health Research and an Associate Editor of the Journal of Periodontology. Robert J. Genco is a State University of New York Distinguished Professor of Oral Biology, and Microbiology, and Immunology at the University at Buffalo. He is also the Vice Provost and Director of the University at Buffalo Office of Science, Technology Transfer and Economic Outreach, and Editor-in-Chief Emeritus of the Journal of Periodontology. Brian A. Burt is Professor Emeritus, Department of Epidemiology, and formerly the Director, Program in Dental Public Health, School of Public Health; and Professor Emeritus, School of Dentistry, University of Michigan, Ann Arbor, MI. He was editor of the journal Community Dentistry and Oral Epidemiology from 1997 to 2007.

1 Clinical and Translational Research: Implications in the Promotion of Oral Health William V. Giannobile 2 Ethics in Oral Health Research Elizabeth Ripley, Francis L. Macrina 3 Responsibilities of Institutions and Individuals in Clinical Research in the Oral Health Sciences Gary C. Armitage 4 Regulatory Process for the Evaluation of Dental Drugs, Devices and Biologics Darnell Kaigler, Kay Fuller, William V. Giannobile 5 Clinical and Translational Research Grantsmanship: Funding Opportunities and Obtaining Research Support Bruce L. Pihlstrom, Michael L. Barnett 6 Data Management in Oral Health Research Bruce A. Dye, Jules T. Mitchel 7 Hypothesis Testing and Avoiding False-Positive Conclusions Philippe P. Hujoel 8 Outcomes in Oral Health Research Amid I. Ismail 9 Examiner Training: Standardization and Calibration in Periodontal Studies Niklaus P. Lang, Mary P. Cullinan, Douglas W. Holborow, Lisa J.A. Heitz-Mayfield 10 Observational Studies in Oral Health Research Hal Morgenstern, Woosung Sohn 11 Initial Clinical Trials Allow Assessment of Safety, Dosing and Preliminary Efficacy Prior to Large Randomized Controlled Pivotal Studies Jules T. Mitchel, Glen Park, Mark Citron, Russ Pagano, Leslie Wisner-Lynch, Samuel E. Lynch 12 Phase III Pivotal Clinical Trials: Clinical Decision-making Norman S. Braveman, Bryan Michalowicz 13 Post-Marketing Surveillance Eugenio D. Beltran-Aguilar, Michael C. Manz 14 Dental Practice-Based Research Networks Donald J. DeNucci and the CONDOR Dental Practice-based Research Networks 15 The Technology Transfer Process for Life Science Innovations in Academic Institutions Robert J. Genco 16 Adoption of New Technologies for Clinical Practice Maxwell H. Anderson 17 Publication of Research Findings James Bader 18 The Evidence-base for Oral Health Helen Worthington, Ian Needleman, Anne-Marie Glenny