Biomarkers for Antioxidant Defense and Oxidative Damage (inbunden)

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Format: Inbunden (Hardback)
Språk: Engelska
Antal sidor: 380
Utgivningsdatum: 2010-09-03
Upplaga: 1
Förlag: Wiley-Blackwell
Illustrationer: Illustrations
Dimensioner: 246 x 173 x 23 mm
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Antal komponenter: 1
ISBN: 9780813815350

Biomarkers for Antioxidant Defense and Oxidative Damage

Principles and Practical Applications

av Giancarlo Aldini, Kyung-Jin Yeum, Etsuo Niki, Robert M Russell

Inbunden, Engelska, 2010-09-03

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Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications critically evaluates the basic concepts and methodologies of conventional biomarkers as well as current state-of-the-art assays for measuring antioxidant activity/oxidative stress and their practical applications. . Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications will be of a great interest to scientists who are involved in basic research on oxidation, applied scientists evaluating the effects of nutraceuticals or pharmaceutical compounds on antioxidant activity/oxidative stress, and physicians who want to understand the degree of oxidative damage in patients with certain chronic diseases. Discovering sensitive and specific biomarkers for systemic oxidative damage is essential to understand the role of oxidative stress in human disease. Once these roles are clearly understood, we are able to identify novel drug and nutraceutical targets. This volume goes beyond conventional analytical methods of measuring overall antioxidant activity and provides insight to the discovery of biomarkers that reveal information on specific areas of oxidative stress. Contributed by an international list of experts, Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications describes both conventional biomarkers and recent developments in this area. Special Features: Discusses conventional biomarkers as well as recent advances for measuring antioxidants and oxidative stress Biomarkers for lipid peroxidation: isoprostane, hydroxyloctadecaenoic acid, oxysterols, and reactive carbonyl species from lipid peroxidation Biomarkers for protein oxidation: carbonylation, tyrosine oxidation, ubiquitin-conjugation Biomarkers for DNA oxidative damage: comet assay, hydroxylated nucleotides, and exocylcic DNA adducts Recently developed biomarkers from cutting-edge technology

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"Chemists, pharmacologists, and other researchers describe the principles behind current methods for measuring antioxidant activity and oxidative stress and their practical applications in specific health situations." (SciTech Book News, December 2010)

Giancarlo Aldini, Ph.D., Department of Pharmaceutical Sciences "Pietro Pratesi", Universita degli Studi di Milano, Milan, Italy Kyung-Jin Yeum, Ph.D., Jean Mayer USDA-Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. Etsuo Niki, Ph.D., , Health Research Institute, National Institute of Advanced Industrial Science & Technology, Osaka, Japan. Robert M. Russell, M.D., Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, MD 20892-7517, USA

Preface vii Contributors ix 1. Antioxidant Activity and Oxidative Stress: An Overview 3 Kyung-Jin Yeum, Robert M. Russell, and Giancarlo Aldini 2. Enzymatic Antioxidant Defenses 21 Sayuri Miyamoto, Hirofumi Arai, and Junji Terao 3. Antioxidants as Biomarkers of Oxidative Stress 35 Ikuyo Ichi and Shosuke Kojo 4. LDL Oxidation as a Biomarker of Antioxidant Status 51 Mohsen Meydani, EunHee Kong, and Ashley Knight 5. The Isoprostanes: Accurate Markers and Potent Mediators of Oxidant Injury in Vivo 65 Joshua D. Brooks, Brian E. Cox, Klarissa D. Hardy, Stephanie C. Sanchez, Sonia Tourino, Tyler H. Koestner, Jocelyn R. Hyman-Howard, and Ginger L. Milne 6. Hydroxyoctadecadienoic Acid (HODE) as a Marker of Linoleic Acid Oxidation 85 Yasukazu Yoshida and Etsuo Niki 7. Oxysterols: Potential Biomarkers of Oxidative Stress 99 Luigi Iuliano and Ulf Diczfalusy 8. Lipid Peroxidation Originating , -unsaturated Aldehydes and Their Metabolites as Biomarkers 117 Francoise Gueraud 9. Oxidative Modifi cation of Proteins: An Overview 137 Paul J. Thornalley and Naila Rabbani 10. Immunochemical Detection of Lipid Peroxidation-specific Epitopes 157 Koji Uchida 11. Mass Spectrometric Strategies for Identification and Characterization of Carbonylated Peptides and Proteins 173 Marina Carini and Marica Orioli 12. Nitrotyrosine: Quantitative Analysis, Mapping in Proteins, and Biological Significance 199 Jose M. Souza, Silvina Bartesaghi, Gonzalo Peluffo, and Rafael Radi 13. Ubiquitin Conjugates: A Sensitive Marker of Oxidative Stress 219 Fu Shang and Allen Taylor 14. Covalent Modifications of Albumin Cys34 as a Biomarker of Mild Oxidative Stress 229 Giancarlo Aldini, Kyung-Jin Yeum, and Giulio Vistoli 15. Protein S-glutathionylation and S-cysteinylation 243 Graziano Colombo, Aldo Milzani, Roberto Colombo, and Isabella Dalle-Donne 16. DNA Oxidation, Antioxidant Effects, and DNA Repair Measured with the Comet Assay 261 Maria Dusinska and Andrew R. Collins 17. Hydroxylated Nucleotides: Measurement and Utility as Biomarkers for DNA Damage, Oxidative Stress, and Antioxidant Efficacy 283 Phyllis E. Bowen 18. Exocyclic DNA Adducts as Biomarkers of Antioxidant Defense and Oxidative Stress 319 Roger W.L. Godschalk Index 333