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Medical and Surgical Management1969
Practical guidance based on expert experience and evidence for developing management strategies for vitiligo This complete guide to vitiligo provides a full appraisal of strategy for the treatment of this autoimmune disease that affects 1-2% of the world's population. It addresses all aspects of vitiligo, covering the science, medical and surgical therapies, and the psychological evaluations and approaches based on the proper understanding of the causes and classification of a particular case. Management of vitiligo is challenging and requires a multipronged approach. Vitiligo: Medical and Surgical Management is a comprehensive, timely, state-of-the-art resource that will help those involved with affected patients better understand and treat this disease, which takes its toll on the mental wellness of those afflicted by it. It takes an evidenced-based approach to the disease's treatment; provides an overview of the surgical management; covers tissue and cellular grafting; and more. Thoroughly guides those involved in the clinical aspects of vitiligo Aids diagnosis and classification of severity Balances evidence and experience Compiled by world-leading expert editors Comprehensive in nature, Vitiligo: Medical and Surgical Management contains a strong practical element, and is a welcome go-to source for practicing dermatologists and those training to become a dermatologist.
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About the Editors Somesh Gupta, MD, DNB, MNAMS, Professor, Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi, India Mats J. Olsson, MD, PhD, CEO, ParkCell AB and President, International Vitiligo Center, Uppsala, Sweden Davinder Parsad, MD, Professor, Department of Dermatology, Venereology & Leprology, Postgraduate Institute of Medical Education & Research, Chandigarh, India Henry W. Lim, MD, Chair Emeritus, Department of Dermatology and Senior Vice President for Academic Affairs, Henry Ford Health System. Past President, American Academy of Dermatology, Detroit, USA Nanja van Geel, MD, PhD, Professor, Department of Dermatology, Ghent University Hospital, Ghent, Belgium Amit G. Pandya, MD, Professor, Department of Dermatology, University of Texas, Southwestern Medical Center, Dallas, USA
List of Contributors xiii Foreword xix Preface xxi About the Companion Website xxiii Section 1 Basic Science 1 1 Introduction 3 Somesh Gupta and Nanja van Geel 2 Melanocyte and Melanogenesis: Applied Anatomy and Physiology 9 Reinhart Speeckaert and Nanja van Geel 3 Epidemiology of Vitiligo 15 Nader Aboul-Fettouh and Amit G. Pandya 4 Pathogenesis of Vitiligo 19 John E. Harris 5 Understanding the Mechanisms of Repigmentation in Vitiligo 27 Ravinder Kumar, Davinder Parsad, and Amrinder J. Kanwar Section 2 Clinical Science 33 6 Classification and Clinical Features of Vitiligo 35 Sang Ho Oh and Seung-Kyung Hann 7 Outcome Measures for Vitiligo 49 Brian Clinton, Viktoria Eleftheriadou, Nanja van Geel, Laila Benzekri, Amit G. Pandya, and Khaled Ezzedine 8 Evaluation and Treatment of the Psychosocial Burden of Vitiligo 61 Vishal Gupta and M. Ramam 9 Patient Support, Education, and Compliance 69 Richard H. Huggins, Jackie Gardner, and Amit G. Pandya 10 Goals of Vitiligo Treatment, and Evidence-Based Practice Guidelines for Medical and Surgical Management 77 Kevin Prier and Amit G. Pandya 11 The Concept of Stability of Vitiligo and Stabilization Therapies 81 Anuradha Bishnoi and Davinder Parsad Section 3 Phototherapy 91 12 Narrow-Band Ultraviolet B Phototherapy in Vitiligo 93 Narumol Silpa-archa and Henry W. Lim 13 UVA-Based Phototherapy: PUVA, PUVA-Sol, and UVA1 Phototherapy 105 Ljubomir B. Novakovic 14 Targeted Phototherapy in Vitiligo 113 Mohammed Al-Jamal, James L. Griffith, Iltefat H. Hamzavi, and Henry W. Lim Section 4 Medical Management 123 15 Immunomodulators and Immunosuppressives in Vitiligo Treatment 125 Anuradha Bishnoi and Davinder Parsad 16 Topical Glucocorticoids, Topical Calcineurin Inhibitors, and Topical Vitamin D3 Analogs 133 Sai Yee Chuah and Boon Kee Goh 17 Other Therapies in Vitiligo 141 Narumol Silpa-archa, James L. Griffith, Iltefat H. Hamzavi, and Pearl E. Grimes 18 Biologic Therapies for Vitiligo 151 Pablo Michel and Amit G. Pandya 19 Evidence Toward Integrated Management of Vitiligo, Combining Ayurveda and Homeopathy with Modern Dermatology 159 Saravu R. Narahari, Madhur G. Aggithaya, Kuthaje S. Bose, and Kodimoole S. Prasanna Section 5 Surgical Therapies: History, Patient Selection, and Classification 171 20 History and Chronology of Development of Surgical Therapies for Vitiligo 173 Koushik Lahiri and Abhishek De 21 Patient Selection, Pre- and Postoperative Information in Surgical Therapies for Vitiligo 185 Nanja van Geel and Mats J. Olsson 22 Classification of Surgical Therapies in Vitiligo 193 James L. Griffith, Mohammed Al-Jamal, and Iltefat H. Hamzavi Section 6 Surgical Therapies: Tissue Grafting 209 23 Minigrafting for Vitiligo 211 Koushik Lahiri 24 Suction Blister Epidermal Grafting 225 Savita Yadav and Somesh Gupta 25 Thin and Ultra-Thin Skin Grafts for Vitiligo 241 Imran Majid 26 Treatment of Leukoderma by Transplantation of Ultra-Thin Epidermal Sheets Using a Motorized Dermatome 249 Mats J. Olsson 27 Mesh Grafts for Vitiligo 257 Chakravarthi R. Srinivas and Reena Rai 28 Smash Grafting 261 Sumit Kar, Ajay Krishnan, and Sudhir Singh 29 Therapeutic Needling and Needling Micrografting 267 Khalifa E. Sharquie and Adil A. Noaimi 30 Complications and Limitations of Melanocyte Transplantation 273 Yvon Gauthier and Laila Benzekri Section 7 Surgical Therapies: Cellular Grafting 279 31 Treatment of Leukoderma by Transplantation of Basal Cell Layer Suspension 281 Mats J. Olsson 32 Non-Cultured Extracted Follicle Outer Root Sheath Cell Suspension Transplantation 293 Kanika Sahni and Somesh Gupta 33 Long-Term Results of Non-Cultured Epidermal Cellular Grafting in Vitiligo 299 Nanja van Geel, Sofie De Schepper, Hilde Lapeere, Barbara Boone, Boon Kee Goh, and Reinhart Speeckaert 34 Simplified Non-Cultured Cellular Grafting 303 Boon Kee Goh 35 Novel Methods of Preparing Epidermal Cell Suspension for Transplantation in Vitiligo 3