Polymorphism in Pharmaceutical Solids (inbunden)
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Format
Inbunden (Hardback)
Språk
Engelska
Antal sidor
656
Utgivningsdatum
2009-07-27
Upplaga
2 ed
Förlag
CRC Press Inc
Illustrationer
200 Illustrations, black and white
Dimensioner
231 x 160 x 41 mm
Vikt
976 g
Antal komponenter
1
ISBN
9781420073218

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Polymorphism in Pharmaceutical Solids (inbunden)

Polymorphism in Pharmaceutical Solids

av Harry G Brittain
Inbunden Engelska, 2009-07-27
2059
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Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins. Topics include: Computational methodologies High-throughput screening methods Pharmaceutical cocrystals Thermally-induced and solution-mediated phase transformations Amorphous solids Crystallography preparation and characterization The amorphous state
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Innehållsförteckning

1. Thermodynamic and Theoretical Issues. 1.1. Theory and Origin of Polymorphism. 1.2. Application of the Phase Rule. 1.3. Computational Methodologies. 2. Preparative Methods for Polymorphs and Solvatomorphs. 2.1. Classical Methods of Preparation. 2.2. High-Throughput Screening Methods. 3. Structural Properties of Polymorphs and Solvatomorphs. 3.1. Polymorphic Systems. 3.2. Solvatomorphic Systems. 3.3. Pharmaceutical Cocrystals. 4. Characterization Methods for Polymorphs and Solvatomorphs. 4.1. Thermal and Crystallographic. 4.2. Vibrational Spectroscopy. 4.3. Solid-State NMR. 4.4. Solubility and Dissolution Rate. 5. Interconversion of Polymorphs and Solvatomorphs. 5.1. Thermally-Induced and Solution-Mediated Phase Transformations. 5.2. Effects of Secondary Processing. 5.3. Structural Aspects of Molecular Dissymmetry. 5.4. Amorphous Solids.